FDA, EMA & WHO Compliant

Cleaning ValidationMade Simple

Calculate Maximum Allowable Carryover (MACO) limits with precision using PDE-based, LD50, and therapeutic dose methods. Complete documentation and 3-year revalidation support included.

69,90049,999+ GSTIntroductory Offer

500+

Pharma Companies

3 Year

Revalidation Cycle

99.9%

Accuracy Rate

MACO Calculator
PDE-Based Calculation

PDE Value

10.0 μg/day

Batch Size

500 kg

MACO Result

2.5 mg

Maximum Allowable Carryover

ICH Q3DEMA Guidelines21 CFR Part 11
Lifetime License

TRUSTED BY LEADING PHARMACEUTICAL COMPANIES WORLDWIDE

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Features

Everything You Need for Cleaning Validation

Comprehensive tools designed specifically for pharmaceutical manufacturing. From calculation to documentation, we have got you covered.

Multiple MACO Methods
Calculate using PDE-based (ICH Q3D), LD50-based toxicological, and therapeutic dose (1/1000th) methods—all in one platform.
Regulatory Compliance
Built to meet FDA, EMA, WHO, and ISPE guidelines. Stay audit-ready with built-in compliance checks and documentation.
Automated Reports
Generate professional validation reports in PDF and Excel formats. Customizable templates with your company branding.
API/Drug Database
Access our comprehensive database of 10,000+ APIs with pre-loaded PDE values, LD50 data, and therapeutic doses.
21 CFR Part 11
Complete audit trail, electronic signatures, and data integrity controls for full regulatory compliance.
Analytics Dashboard
Track cleaning validation trends, identify equipment risks, and optimize your cleaning procedures with data insights.
Team Collaboration
Role-based access control, shared workspaces, and real-time collaboration for QA, QC, and production teams.
Version Control
Track all changes with complete revision history. Compare versions and maintain compliance documentation.
Multi-Site Support
Manage cleaning validation across multiple manufacturing sites with centralized control and local customization.

How It Works

From Input to Validation in Minutes

Our streamlined workflow takes you from data entry to audit-ready documentation in four simple steps.

01

Input Your Data

Enter product details, equipment specifications, and select your preferred calculation method. Our smart forms guide you through each field.

  • Product A and B parameters
  • Equipment surface area
  • Batch sizes and daily doses
02

Calculate MACO

Our engine instantly calculates MACO limits using your chosen methodology, applying the latest regulatory guidelines automatically.

  • PDE-based calculation
  • Safety factor application
  • Worst-case scenario analysis
03

Review Results

View detailed results with clear breakdowns, visual representations, and compliance status indicators for easy interpretation.

  • Limit per surface area
  • Swab and rinse limits
  • Visual compliance indicators
04

Generate Reports

Export comprehensive validation reports ready for regulatory submission. Includes all calculations, references, and audit trails.

  • PDF/Excel export
  • Digital signatures
  • Complete audit trail

Why MACO Pro

Transform Your Cleaning Validation Process

Join hundreds of pharmaceutical companies who have modernized their cleaning validation workflows. Our platform delivers measurable improvements in efficiency, accuracy, and compliance.

Save 80% Time

Automate tedious calculations and report generation. What took hours now takes minutes.

Reduce Compliance Risk

Built-in regulatory checks ensure your validations meet FDA, EMA, and WHO standards every time.

Improve Accuracy

Eliminate manual calculation errors with validated algorithms and automatic unit conversions.

Audit-Ready Always

Complete documentation with full traceability. Pass audits with confidence.

Complete Documentation

All validation documents (IQ/OQ/PQ) provided by vendor. No additional documentation effort needed.

Cost-Effective

One-time license at ₹49,999 with no recurring monthly fees. Predictable 3-year cycles.

Proven Results

Time Saved on Calculations80%
Reduction in Calculation Errors95%
Customer Satisfaction98%
Regulatory Audit Pass Rate100%

Based on feedback from 500+ pharmaceutical companies using MACO Pro across India

Pricing

Simple, Transparent Licensing

One-time license with complete documentation. First revalidation after 1 year, then every 3 years.

License Lifecycle

Day 1

Purchase License

₹49,999 + GST

1 Yr

1st Revalidation

₹25,000 + GST

4 Yr

2nd Revalidation

₹25,000 + GST

7 Yr

3rd Revalidation

₹25,000 + GST

First revalidation required after 1 year, then every 3 years thereafter for continued compliance

Introductory Offer
MACO Pro License
One-time purchase, lifetime ownership
69,900
49,999+ GST

One-time payment for perpetual license

Save ₹19,901 - Limited Time Offer

Everything included:

  • All MACO calculation methods (PDE, LD50, Therapeutic Dose)
  • FDA, EMA & WHO compliant calculations
  • Complete validation documentation package
  • 21 CFR Part 11 compliance features
  • Audit trail & electronic signatures
  • API/Drug database with 10,000+ compounds
  • PDF & Excel report generation
  • Custom report templates with company branding
  • Unlimited calculations during license period
  • Email & phone support
  • Free software updates during license period
  • Training & onboarding session included

Secure payment via bank transfer or UPI. GST invoice provided.

Revalidation Package
Required for continued compliance
25,000+ GST

Per revalidation cycle

Schedule:

  • First revalidation: After 1 year from purchase
  • Subsequent revalidations: Every 3 years

Revalidation includes:

  • Complete re-certification of software
  • Updated validation documentation (IQ/OQ/PQ)
  • Latest regulatory compliance updates
  • Database refresh with new compounds
  • Continued technical support for 3 years
  • All new features & updates included
  • License reactivation
Non-Compliance Notice

If revalidation is not completed on time, the following restrictions will apply:

  • PDF report export will be disabled
  • Limited access to guideline compliance features
  • Software will not be audit-ready

Revalidation charge of ₹25,000 + GST covers validation documentation renewal

Enterprise / Multi-Site

Need licenses for multiple sites or custom integrations? Contact us for volume pricing and enterprise solutions.

All prices are in Indian Rupees (INR). 18% GST applicable. Payment via bank transfer, UPI, or cheque.

License Purchase

Purchase MACO Pro License

Complete the form below to purchase your license. Your license key will include your company logo and name displayed in the application header.

Order Summary

MACO Pro License
69,90049,999
GST (18%)9,000
Total Payable58,999

Limited Time Offer - Save ₹19,901

What's Included

  • Perpetual software license
  • Complete validation docs (IQ/OQ/PQ)
  • Custom branding in app header
  • 1 year software updates & support
  • Training & onboarding session

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MACO Pro Licensed

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For HODs & Enterprise Stakeholders

Request Enterprise Trial Access

Get a personalized trial with your company branding. Your license key will display your company name and logo in the application header.

Custom License Key Benefits

  • Company Branding

    Your logo and company name displayed in app header

  • Multi-User Access

    Add multiple stakeholder emails for trial access

  • Full Feature Access

    All premium features unlocked during trial

  • 30-Day Trial Period

    Extended evaluation with dedicated support

License Key Preview

Your Company Name

MACO Pro Licensed

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Documentation

Comprehensive Resources for Every User

From quick start guides to advanced API documentation, we provide everything you need to get the most out of MACO Pro.

Getting Started Guide
Learn the basics of MACO Pro and set up your first cleaning validation project in minutes.
API Reference
Integrate MACO Pro with your existing systems using our comprehensive REST API.
Video Tutorials
Step-by-step video guides covering all features and best practices.
Regulatory Guides
Understand FDA, EMA, and WHO requirements for cleaning validation.
api-example.ts
// Calculate MACO using PDE method
const result = await macopro.calculate({
  method: "PDE",
  productA: {
    name: "Ibuprofen",
    pde: 10.0, // μg/day
    batchSize: 500 // kg
  },
  productB: {
    minDailyDose: 100 // mg/day
  },
  equipment: {
    surfaceArea: 25000 // cm²
  }
});

console.log(result.maco); // 2.5 mg

Pro tip: Use our SDK for JavaScript, Python, and R to integrate MACO calculations directly into your existing workflows.

Our Mentors & Advisors

Built with Guidance from Industry Experts

MACO Pro was developed with invaluable insights and mentorship from these distinguished pharmaceutical professionals who shaped our vision and validated our approach.

Dr. [Name]
Regulatory Guidance & GMP Compliance

"Your validation software addresses a critical gap in the pharmaceutical industry. The approach to MACO calculations following current guidelines will significantly improve compliance standards across manufacturing units."

Dr. [Name]

Head of Quality Assurance

[Organization Name]

Dr. [Name]
Scientific Methodology & PDE Calculations

"The scientific methodology behind the calculations is robust and aligns perfectly with ICH guidelines. This tool will empower QA teams to make data-driven decisions with confidence."

Dr. [Name]

Director of Pharmaceutical Sciences

[Organization Name]

Dr. [Name]
Validation Protocols & Documentation

"Having spent decades in cleaning validation, I can confidently say this software simplifies complex calculations while maintaining scientific rigor. It's a game-changer for the industry."

Dr. [Name]

Chief Validation Officer

[Organization Name]

We extend our heartfelt gratitude to these visionary leaders whose expertise, guidance, and unwavering support made MACO Pro possible. Their dedication to advancing pharmaceutical quality standards continues to inspire our mission.

Testimonials

Trusted by Quality Leaders Worldwide

See what pharmaceutical professionals say about their experience with MACO Pro.

"MACO Pro transformed our cleaning validation process. What used to take our team days now takes hours, and we have complete confidence in our compliance status."
DSC

Dr. Sarah Chen

Director of Quality Assurance, PharmaTech Industries

"The audit trail and 21 CFR Part 11 compliance features made our FDA inspection seamless. The inspectors were impressed with our documentation quality."
MR

Michael Rodriguez

Validation Manager, BioGenesis Labs

"We evaluated several solutions, but MACO Pro is the only one that truly understands pharmaceutical requirements. The PDE database alone saved us months of work."
DEW

Dr. Emily Watson

Chief Scientific Officer, Meridian Pharmaceuticals

FAQ

Frequently Asked Questions

Everything you need to know about MACO Pro licensing and features. Cannot find the answer you are looking for? Contact our team.

Ready to Simplify Your Cleaning Validation?

Get your MACO Pro license today and join 500+ pharmaceutical companies who trust our solution for their cleaning validation needs.

Call Us

+91 98765 43210

Mon-Sat, 9 AM - 6 PM IST

Email Us

sales@macopro.in

We respond within 24 hours

Visit Us

Ahmedabad, Gujarat, India

By appointment only

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Happy Customers

100%

Audit Pass Rate

24h

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